David Lynch's Mulholland Drive is structured as a dream that ruptures into its own reality midway through — Hollywood mythology weaponized against Hollywood. It is the film most often cited by critics as the best of the 21st century, and the one viewers most often watch twice trying to understand.
Lynch flips his neo-noir inside out at the two-hour mark and dares you to keep believing any of it — the film is a Möbius strip of identity.